IGF-II: Products

IGF-II (Insulin-like growth factor II; also multiplication-stimulating polypeptide/MSP and somatomedin-A) belongs to the insulin family of peptide growth factors. It is part of a complex system of growth and metabolic-regulating proteins that is particularly important during development. It has been associated with nervous system proliferation and differentiation, myelination, adrenal cortical proliferation, and skeletal growth and differentiation. In human, IGF-II is primarily synthesized by the liver, and circulates at high levels in both fetus and adult. In rodent, however, IGF-II levels drop after the perinatal period. IGF-II is produced by astrocytes, hepatocytes, osteoblasts, embryonic striated muscle cells plus Kupffer cells and Ito cells. IGF-II binds to IGF-I R, Insulin R (IR)-type A, IGF-I R:Insulin R-A hybrids, IGF-II R, and IGF binding proteins 1-6. The first three receptors initiate downstream signaling events, the IGF-II R sequesters local IGF-II, and the six IGFBPs regulate IGF-II activity in various tissues.

Showing 1-7 out of 7 IGF-II Products

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B/N, IHC, WBAF-292-NA5  
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B/N, IHC, WBAF7924  
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ELISA(Cap), WBMAB7922  
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B/NMAB2922  
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ELISA(Det), WBBAF7922  
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WBBAF2921  
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WBMAB2921 
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