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IL-17E/IL-25: Products

IL-17E/IL-25 (Interleukin-25) is a cytokine that promotes Th2-biased immune responses. This is in contrast to other IL-17 family members which promote Th1- and Th17-biased inflammation. IL-25 is an important mediator of allergic reactions and protection against intestinal parasites. During helminth infections and allergic reactions, IL-25 is locally upregulated in intestinal and airway epithelial cells, atopic dermatitis skin lesions, and local Th2 cells, eosinophils, and basophils. It binds to IL-17 RB but also requires IL-17 RA to exert its activity. IL-25 acts on a variety of cell types which respond with increased production of Th2 cytokines (e.g. IL-4, IL-5, IL-13) and reduced production of Th1 and Th17 cytokines (e.g. IFN-gamma, IL-12, IL-23, IL-17A, IL-17F). Airway IL-25 can be activated by MMP-7, a protease that is upregulated in airway epithelium in response to allergen exposure. Cleaved IL-25 shows enhanced binding to IL-17 RB and stronger induction of Th2 cytokines. IL-25 also promotes vascular endothelial cell proliferation and assembly into tubular structures. It supports the integrity of the blood-brain barrier and limits CD4+ T cell infiltration into the brain.

Showing 1-28 out of 28 IL-17E/IL-25 Products

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Human Magnetic Luminex Assay

LXSAHM 
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Recombinant Mouse IL-17E Protein, CF

 1399-IL/CF 
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Recombinant Mouse IL-17E Protein

 1399-IL 
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Human Luminex Assay

LXSAH 
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Build your own with our Luminex Assay Customization Tool.

Recombinant Human IL-17E Protein

 1258-IL 
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Recombinant Human IL-17E Protein, CF

 1258-IL/CF 
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Proteome Profiler Human Cytokine Array Kit


Contains 4 membranes - each spotted in duplicate with 36 different cytokine antibodies
ARY005B 
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Mouse IL-17E DuoSet ELISA

ELISADY1399 
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Human IL-17E/IL-25 Antibody

Flow, WBMAB1258 
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Human IL-17E/IL-25 Biotinylated Antibody

WBBAF1258 
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Mouse IL-17E/IL-25 Biotinylated Antibody

ELISA(Det), WBBAF1399 
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Recombinant Human IL-17E (Human Cell-expressed) Protein

 8134-IL 
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Mouse IL-17E/IL-25 Antibody

ELISA(Cap), FlowMAB13991 
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Mouse IL-17E/IL-25 Antibody

WBAF1399 
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Recombinant Human IL-17E (Human Cell-expressed) Protein, CF

 8134-IL/CF 
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Human IL-17E/IL-25 PE-conjugated Antibody

FlowIC1258P 
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Mouse IL-17E/IL-25 Antibody

B/NMAB13992 
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Recombinant Human IL-17E GMP Protein, CF

 1258-GMP 
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Human IL-17E/IL-25 Antibody

B/N, WBAF1258 
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Mouse IL-17E/IL-25 Antibody

WBMAB1399 
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Human IL-17E/IL-25 APC-conjugated Antibody

FlowIC1258A 
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Recombinant Mouse IL-17E (NS0-expressed) Protein, CF

 7909-IL/CF 
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Mouse IL-17E/IL-25 PE-conjugated Antibody

FlowIC13991P 
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Human IL-17E/IL-25 Fluorescein-conjugated Antibody

FlowIC1258F 
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Human IL-17E DuoSet ELISA

ELISADY1258-05 
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Recombinant Mouse IL-17E (NS0-expressed) Protein

 7909-IL 
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Recombinant Rat IL-17E Protein

 8949-IL 
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Recombinant Rat IL-17E Protein, CF

 8949-IL/CF 
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