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IL-27: Products

Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the 28 kDa glycoprotein that is related to the p35 chain of IL-12). The human EBI3 gene encodes a 229 amino acid (aa) precursor that contains a 20 aa signal peptide and 209 aa mature protein. The mature region contains two potential N-linked glycosylation sites, two fibronectin type III domains, and two pairs of conserved cysteine residues with a WSxWS-like motif that places the IL-27 molecule in the hematopoietin receptor family. Although p40, the EBI3 counterpart in IL-12, is known to form homodimers, there is no evidence to date that EBI3 also homodimerizes.

Human EBI3 is 61% aa identical to mouse EBI3. The human p28 gene encodes a 243 aa precursor that contains a 28 aa signal sequence and 215 aa mature region. The mature region is characterized by the presence of four α-helices, placing it in the IL-6 family of helical cytokines. Human p28 is 74% aa identical to mouse p28. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX-1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and pro-inflammatory properties. As an anti-inflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naïve CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development).

Showing 1-20 out of 20 IL-27 Products

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Human Magnetic Luminex Assay

LXSAHM7  
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Recombinant Human IL-27 Protein

 2526-IL14  
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Recombinant Human IL-27 Protein, CF

 2526-IL/CF14  
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Human Luminex Assay

LXSAH4  
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Recombinant Mouse IL-27 (NS0-expressed) Protein, CF

 2799-ML/CF15  
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Recombinant Mouse IL-27 (NS0-expressed) Protein

 2799-ML15  
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Human IL-27 Antibody

B/N, ELISA(Cap), WBAF25263  
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Proteome Profiler Mouse Cytokine Array Kit, Panel A


Contains 4 membranes - each spotted in duplicate with 40 different cytokine antibodies
ARY00696  
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Human IL-27 DuoSet ELISA

ELISADY25269  
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Human IL-27 Biotinylated Antibody

ELISA(Det), WBBAF25261  
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Proteome Profiler Human XL Cytokine Array Kit


Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
ARY022B5  
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Human IL-27 Antibody

FlowMAB252611  
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Mouse IL-27 PE-conjugated Antibody

FlowIC1834P 
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Human IL-27 APC-conjugated Antibody

FlowIC25261A 
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Human IL-27 Fluorescein-conjugated Antibody

FlowIC25261F 
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Human IL-27 PE-conjugated Antibody

FlowIC25261P 
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Mouse IL-27 Fluorescein-conjugated Antibody

FlowIC1834F 
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Mouse IL-27 Antibody

IPMAB18343 
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Mouse IL-27 APC-conjugated Antibody

FlowIC1834A 
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Mouse IL-27 Antibody

FlowMAB18342 
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