Filter Results
clear

By Category

By Common Name

clear

By Applications

clear

By Conjugate

clear

By Clonality

clear

By Host

clear

By Isotype

clear

By Clone

clear

By Citation

clear

By Sample Size

clear

By Low Endotoxin

clear

By Brand

IL-27 p28/IL-30: Products

Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the 28 kDa glycoprotein that is related to the p35 chain of IL-12). The human EBI3 gene encodes a 229 amino acid (aa) precursor that contains a 20 aa signal peptide and 209 aa mature protein. The mature region contains two potential N-linked glycosylation sites, two fibronectin type III domains, and two pairs of conserved cysteine residues with a WSxWS-like motif that places the IL-27 molecule in the hematopoietin receptor family. Although p40, the EBI3 counterpart in IL-12, is known to form homodimers, there is no evidence to date that EBI3 also homodimerizes.

Human EBI3 is 61% aa identical to mouse EBI3. The human p28 gene encodes a 243 aa precursor that contains a 28 aa signal sequence and 215 aa mature region. The mature region is characterized by the presence of four α-helices, placing it in the IL-6 family of helical cytokines. Human p28 is 74% aa identical to mouse p28. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX-1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and pro-inflammatory properties. As an anti-inflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naïve CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development).

Showing 1-9 out of 9 IL-27 p28/IL-30 Products

page of 1
Results Per Page
DescriptionApplicationCat#CitationsImages 

Mouse IL-27 p28/IL-30 Antibody

B/N, IHC, WBAF183410  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse IL-27 p28/IL-30 Quantikine ELISA Kit

ELISAM272813  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Recombinant Mouse IL-27 p28/IL-30 Protein

 7430-ML 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Recombinant Mouse IL-27 p28/IL-30 Protein, CF

 7430-ML/CF 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse IL-27 p28/IL-30 DuoSet ELISA

ELISADY18345  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse IL-27 p28/IL-30 Biotinylated Antibody

WBBAF18343  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse IL-27 p28/IL-30 Antibody

Flow, WBMAB1834 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse IL-27 p28/IL-30 Antibody

WBMAB7430 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Proteome Profiler Mouse XL Cytokine Array


Contains 4 membranes-each spotted in duplicate with 111 different cytokine antibodies
ARY028 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page