IL-27/IL-35 EBI3 Subunit: Products

Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the 28 kDa glycoprotein that is related to the p35 chain of IL-12). The human EBI3 gene encodes a 229 amino acid (aa) precursor that contains a 20 aa signal peptide and 209 aa mature protein. The mature region contains two potential N-linked glycosylation sites, two fibronectin type III domains, and two pairs of conserved cysteine residues with a WSxWS-like motif that places the IL-27 molecule in the hematopoietin receptor family. Although p40, the EBI3 counterpart in IL-12, is known to form homodimers, there is no evidence to date that EBI3 also homodimerizes.

Human EBI3 is 61% aa identical to mouse EBI3. The human p28 gene encodes a 243 aa precursor that contains a 28 aa signal sequence and 215 aa mature region. The mature region is characterized by the presence of four α-helices, placing it in the IL-6 family of helical cytokines. Human p28 is 74% aa identical to mouse p28. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX-1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and pro-inflammatory properties. As an anti-inflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naïve CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development).

Showing 1-7 out of 7 IL-27/IL-35 EBI3 Subunit Products

page of 1
Results Per Page
DescriptionApplicationCat#CitationsImages 

Mouse IL-27/IL-35 EBI3 Subunit Antibody

WBMAB183413  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human IL-27/IL-35 EBI3 Subunit APC-conjugated Antibody

FlowIC6456A1  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human IL-27/IL-35 EBI3 Subunit Antibody

FlowMAB6456 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse IL-27/IL-35 EBI3 Subunit PE-conjugated Antibody

FlowIC18341P 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse IL-27/IL-35 EBI3 Subunit APC-conjugated Antibody

FlowIC18341A 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse IL-27/IL-35 EBI3 Subunit PerCP-conjugated Antibody

FlowIC18341C 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page