IL-1 beta/IL-1F2: Products

IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.

Showing 1-25 out of 25 IL-1 beta/IL-1F2 Products

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 201-LB/CF169  
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 201-LB169  
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 401-ML/CF58  
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 401-ML58  
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 501-RL25  
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 501-RL/CF25  
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 681-PI5  
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 681-PI/CF5  
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 201-GMP 
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 3340-EL1  
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 3340-EL/CF1  
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 1318-RL1  
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 1318-RL/CF1  
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 7464-RB 
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 7464-RB/CF 
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 3747-CL/CF 
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 3747-CL 
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 1796-FL 
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 1009-CL 
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 1009-CL/CF 
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 1796-FL/CF 
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 AFL201 
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 AFL401 
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 6226-GL 
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 6226-GL/CF 
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