IL-13: Products

IL-13 (Interleukin-13) plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. It promotes B cell activation, immunoglobulin class switching to IgE, and the upregulation of CD23/Fc epsilon RII. IL-13 signals through a receptor complex containing IL-13 R alpha 1 and IL-4 R alpha. This complex also functions as the type 2 IL-4 receptor. IL-13 R alpha 2 binds IL-13 and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex. IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis.

Showing 1-12 out of 12 IL-13 Products

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 213-ILB/CF30  
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 213-ILB30  
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 413-ML/CF30  
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 413-ML30  
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 1945-RL/CF2  
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 1945-RL2  
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 5894-CL 
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 2674-RM1  
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 5894-CL/CF 
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 2674-RM/CF1  
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 6940-CL 
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 6940-CL/CF 
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