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IL-18/IL-1F4: Products

IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.

Showing 1-7 out of 7 IL-18/IL-1F4 Products

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Human Magnetic Luminex Assay

LXSAHM62  
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Build your own with our Luminex Assay Customization Tool.

Human IL-18/IL-1F4 ELISA


Human IL-18/IL-1F4 Quantikine ELISA Kit is now available, catalog # DL180.
ELISA762038  
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Human IL-18/IL-1F4 Antibody

B/N, ELISA(Cap), IPD044-318  
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Mouse IL-18/IL-1F4 ELISA

ELISA762531  
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Recombinant Human IL-18/IL-1F4 Protein


A New rhIL-18 is Now Available! Competitively priced; Higher purity; Lower endotoxin; Manufactured in-house!
New Product 9124-IL
BioactivityB001-530  
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Recombinant Mouse IL-18/IL-1F4 Protein


A New rmIL-18 is Now Available! Competitively priced; Enhanced stability; Lower endotoxin specifications; Made in-house!
New Product 9139-IL
 B002-527  
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Proteome Profiler Human Cytokine Array Kit


Contains 4 membranes - each spotted in duplicate with 36 different cytokine antibodies
ARY005B136  
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