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IL-20 R alpha: Products

IL-20 receptor alpha (IL-20 R alpha), also named IL-20 R1, CRF2-8, and ZCYTOR7, belongs to the class II cytokine receptor family, which includes 12 members. These receptors are characterized by the patterns of conserved amino acid residues (aa) in their extracellular domains, which are composed of tandem fibronectin type III domains. Class II cytokine receptors form heterodimeric signaling receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions. The gene for human IL-20 R alpha is mapped to chromosome 6 and encodes a 553 aa glycoprotein with a 29 aa signal peptide, a 221 aa extracellular domain, a 24 aa transmembrane region and a 279 aa intracellular domain.

IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland. The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells. IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals. IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26. Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes.

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Human IL-20 R alpha Antibody

Clonality: Monoclonal
Host: Mouse IgG1 Clone #173707
Applications: IHC
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MAB11761

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IL-20 Ra in Human Skin.

Human IL-20 R alpha Antibody

Clonality: Monoclonal
Host: Mouse IgG1 Clone #173714
Applications: Flow, WB
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MAB11762

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Human IL‑20 R alpha Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: WB, Flow
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AF1176

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Mouse IL-20 R alpha Antibody

Clonality: Polyclonal
Host: Sheep IgG
Applications: WB
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AF1736

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Human IL‑20 R alpha Antibody

Clonality: Monoclonal
Host: Mouse IgG2a Clone #173722
Applications: WB
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MAB1176

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Mouse IL‑20 R alpha Antibody

Clonality: Monoclonal
Host: Rat IgG1 Clone #227702
Applications: WB
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MAB1736

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Human IL‑20 R alpha PE‑conjugated Antibody

Clonality: Monoclonal
Host: Mouse IgG1 Clone #173714
Applications: Flow
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FAB11762P

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Detection of IL-20 Ra in BaF3 Mouse Cell Line Transfected with Human IL-20 Ra and eGFP by Flow Cytometry.

Mouse IL-20 R alpha Biotinylated Antibody

Clonality: Polyclonal
Host: Sheep IgG
Applications: WB
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BAF1736

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Human IL‑20 R alpha Biotinylated Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: WB, Flow
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BAF1176

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Human IL-20 R alpha APC-conjugated Antibody

Clonality: Monoclonal
Host: Mouse Clone #173714
Applications: Flow
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FAB11762A

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