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IL-6: Products

Interleukin 6 (IL-6), also known as interferon-beta 2, 26 kDa protein and B cell stimulatory factor-2 (BSF-2), is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22 kDa - 28 kDa phosphorylated and variably glycosylated molecule. Mature human IL-6 is 183 amino acids (aa) in length and shares 41% aa sequence identity with mouse and rat IL-6. Alternate splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties.

IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R, triggering IL-6 R association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R are generated by both alternate splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R elicit responses from gp130-expressing cells that lack cell surface IL-6 R. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R is predominantly restricted to hepatocytes, leukocytes, and lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R but not from other cytokines that utilize gp130 as a coreceptor.

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Human IL-6 Quantikine ELISA Kit

180 Citations
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D6050

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IL
DATA_IL6_D6050_ELISA_556.jpg
DATA_IL6_D6050_ELISA_555.jpg

Mouse IL-6 Quantikine ELISA Kit, 2 Plate

176 Citations
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M6000B

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DATA_IL6_M6000_ELISA_936.jpg

Recombinant Human IL-6 Protein

100 Citations
Source: E. coli
Accession #: Q75MH2
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206-IL

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IL 6_206
IL 6_206

Recombinant Human IL-6 Protein, CF

100 Citations
Source: E. coli
Accession #: Q75MH2
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206-IL/CF

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IL 6_206
IL 6_206

Human IL-6 Quantikine HS ELISA Kit

98 Citations
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HS600B

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IL

Mouse IL-6 DuoSet ELISA, 15 Plate

98 Citations
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DY406

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Recombinant Mouse IL-6 Protein

79 Citations
Source: E. coli
Accession #: P08505
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406-ML

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IL 6_406
IL 6_406

Recombinant Mouse IL-6 Protein, CF

79 Citations
Source: E. coli
Accession #: P08505
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406-ML/CF

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IL 6_406
IL 6_406

Human IL-6 DuoSet ELISA, 15 Plate

69 Citations
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DY206

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Rat IL-6 Quantikine ELISA Kit

37 Citations
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R6000B

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IL
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