IRF3: Products

Interferon regulator transcription factors (IRF) are a family characterized by a helix-turn-helix DNA binding domain enriched in tryptophan repeats. IRF family members show diverse cellular regulation of interferon-stimulated gene transcription, viral-mediated gene activation, apoptosis, differentiation, and cellular growth. IRF2 functions as a regulator of type I interferons influencing cellular proliferation and immune response through transcriptional regulation. IRF2 competitively inhibits IRF1 gene activation, as well as, stimulating transcription on its own.

Interferon response factor 3 (IRF3) is a 50 kDa, 427 amino acid, member of the IRF family of proteins. Human IRF3 is a transcription factor that binds the interferon-sensitive response element (ISRE) and is activated by Toll-like receptors, TLR3 and TLR4. Viral entry or engagement of TLR3 or TLR4 stimulates IRF3 phosphorylation, nuclear translocation and stimulation of IFN production. There are potential alternate splice forms affecting IRF3 structure, one including a deletion of aa 201 - 327, a second with the same deletion and an alternate Met147 start site, and a third with a 125 aa substitution of the C-terminal 100 aa.

Showing 1-7 out of 7 IRF3 Products

page of 1
Results Per Page
DescriptionApplicationCat#CitationsImages 

Human IRF3 Antibody

Flow, ICC/IF, WBAF4019 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human IRF3 Antibody

Flow, WBMAB4019 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Mouse IRF3 Antibody

WBAF4454 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human IRF3 PE-conjugated Antibody

FlowIC4019P 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human IRF3 APC-conjugated Antibody

FlowIC4019A 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human IRF3 Alexa Fluor® 488-conjugated Antibody

FlowIC4019G 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Proteome Profiler Human Ubiquitin Array


Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
ARY027 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page