ISG15/UCRP: Products

Interferon-stimulated Gene 15 (ISG15), also known as Ubiquitin Cross-reacting Protein (UCRP), is a Ubiquitin-like protein that is covalently coupled to target proteins in a process termed ISGylation. It is a 165 amino acid (aa) polypeptide with a predicted molecular weight of 18 kDa. ISG15/UCRP exhibits 66% aa sequence identity with its mouse ortholog. Structurally, ISG15/UCRP consists of two tandem Ubiquitin-like domains that share a similar 3-dimensional structure with Ubiquitin and other Ubiquitin-like modifiers including NEDD8 and SUMO1. Modification of targets by ISG15/UCRP occurs in a stepwise enzymatic process similar to that of Ubiquitin. Enzymes regulating ISGylation include the activating (E1) enzyme UBE1L, the conjugating (E2) enzyme UbcH8, and ligases (E3) such as EFP/TRIM25 and HERC5. Removal of ISG15/UCRP is catalyzed by the deconjugating enzyme UBP43/USP18. Functionally, ISG15/UCRP has putative roles in the immune response and tumorigenesis. This is reflected by intracellular ISG15/UCRP targets that include Cyclin D1, tumor suppressor p63, IRF3, and a range of viral proteins. It is induced by type 1 interferons and microbial infection, and knockout mice exhibit an increased sensitivity to infection by some viruses. ISG15/UCRP can also be secreted by cells of the immune system and may act in a cytokine-like manner. For instance, it is produced by human granulocytes in response to mycobacterium exposure, and natural killer cells and T cells respond to extracellular ISG15/UCRP with IFN-gamma production. Further supporting a role in immune function, ISG15/UCRP mutations are associated with MSMD, an inherited disorder characterized by increased susceptibility to mycobacterial infection.

Showing 1-20 out of 20 ISG15/UCRP Products

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Recombinant Human ISG15 AMC Protein, CF

 UL-5532  
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Human ISG15/UCRP Antibody

IHC, WBMAB48451  
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Human ISG15/UCRP Alexa Fluor® 488-conjugated Antibody

FlowIC8044G 
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Recombinant Human ISG15 Protein, CF

 UL-6011  
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Human ISG15/UCRP Antibody

WBAF4845 
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Human ISG15/UCRP APC-conjugated Antibody

FlowIC8044A 
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Human ISG15/UCRP Antibody

WBA-600 
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Human ISG15/UCRP Antibody

IP, WBA-830 
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Human ISG15/UCRP PE-conjugated Antibody

FlowIC8044P 
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Recombinant Human His6-Pro-ISG15 Protein, CF

 UL-620 
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Recombinant Human Pro-ISG15 Protein, CF

 UL-615 
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Recombinant Human ISG15 Agarose Protein, CF

 UL-630 
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Recombinant Human ISG15 Vinyl Sulfone Protein, CF

 UL-603 
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Recombinant Human ISG15 Protein, Low Endotoxin, CF

 UL-605 
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ISG15 Conjugation Kit

K-600 
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Recombinant Human His6-ISG15 Protein, CF

 UL-610 
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Recombinant Human ISG15 Rhodamine Protein, CF

 UL-614 
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Recombinant Human ISG15 Biotin Protein, CF

 UL-612 
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Recombinant Human ISG15 Fluorescein Protein, CF

 UL-613 
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Recombinant Human GST-ISG15 Protein, CF

 UL-600 
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