Integrin Receptor Inhibitors: Products

Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Showing 1-17 out of 17 Integrin Receptor Inhibitors Products

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BIO 5192


Highly potent and selective inhibitor of integrin alpha4beta1
5051 
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BIO 1211


Selective alpha4beta1 (VLA-4) inhibitor
39102  
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RGDS peptide


Integrin binding sequence; inhibits integrin receptor function
34982  
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TC-I 15


Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo
4527 
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Eptifibatide


Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation
4725 
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BTT 3033


Selective inhibitor of integrin alpha2beta1
4724 
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Echistatin, α1 isoform


alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor
32022  
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TCS 2314


alpha4beta1 (VLA-4) antagonist
3900 
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GR 144053 trihydrochloride


Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic
1263 
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A 286982


Potent inhibitor of the LFA-1/ICAM-1 interaction
4228 
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Obtustatin


Potent and selective alpha1beta1 inhibitor
4664 
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BIRT 377


Potent negative allosteric modulator of LFA-1
4776 
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P11


Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic
4744 
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RWJ 50271


Inhibitor of LFA-1/ICAM mediated cell adhesion
4227 
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ATN 161


alpha5beta1 integrin receptor antagonist
6058 
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MNS


Selective inhibitor of Src and Syk
2877 
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Cilengitide


Potent and selective inhibitor of integrins alphavbeta3 and alphavbeta5
5870 
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