Integrin Receptor Inhibitors: Products

Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Showing 1-19 out of 19 Integrin Receptor Inhibitors Products

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BIO 1211


Selective α4β1 (VLA-4) inhibitor
39102
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RGDS peptide


Integrin binding sequence; inhibits integrin receptor function
34984
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BIO 5192


Highly potent and selective inhibitor of integrin α4β1
50511
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ATN 161


α5β1 integrin receptor antagonist
6058
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Echistatin, α1 isoform


αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
32022
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Cilengitide


Potent and selective inhibitor of integrins αvβ3 and αvβ5
5870
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GR 144053 trihydrochloride


Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
1263
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TCS 2314


α4β1 (VLA-4) antagonist
3900
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RWJ 50271


Inhibitor of LFA-1/ICAM mediated cell adhesion
42271
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A 286982


Potent inhibitor of the LFA-1/ICAM-1 interaction
4228
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TC-I 15


Potent α2β1 inhibitor; displays antithrombotic activity in vivo
4527
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Obtustatin


Potent and selective α1β1 inhibitor
4664
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BTT 3033


Selective inhibitor of integrin α2β1
4724
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Eptifibatide


Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation
4725
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P11


Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
47441
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BIRT 377


Potent negative allosteric modulator of LFA-1
4776
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MNS


Selective inhibitor of Src and Syk
2877
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BOP


Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs
6047
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R-BC154


High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs
6048
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