Integrin alpha 2 beta 1: Products

Integrin alpha 2 beta 1 (VLA-2) is one of twelve Integrin family adhesion receptors that share the beta 1 subunit. It is one of six very late antigens expressed on activated T cells. Divalent cations and intracellular (inside-out) signaling convert it to its most active, extended, and open conformation. alpha 2 beta 1 binds to Collagen types I, II, and III, Laminin, Decorin, E‑Cadherin, and Collectin molecules such as C1q. Platelet a2b1, also called GPIa, cooperates with GPVI to coordinate platelet collagen binding and activation. Adhesion is enhanced by crosstalk with Syndecan-1 or HGF R/c-Met and antagonized by crosstalk with Integrin a1b1. a2b1 is additionally expressed on select hematopoietic and non‑hematopoietic cells.

 

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Recombinant Human Integrin alpha 2 beta 1 Protein, CF

Binding Activity5698-A22  
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TC-I 15


Potent α2β1 inhibitor; displays antithrombotic activity in vivo
45271
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BTT 3033


Selective inhibitor of integrin α2β1
47241
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Recombinant Mouse Integrin alpha 2 beta 1 Protein, CF

Bioactivity7828-A2 
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