Integrin alpha 2/CD49b: Products

Integrin alpha 2 is one of twelve Integrin alpha subunits that associates with the beta 1 subunit. Integrin alpha 2 beta 1 (VLA-2) is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is one of six very late antigens expressed on activated T cells. Divalent cations and intracellular (inside-out) signaling convert it to its most active, extended, and open conformation. a2b1 binds to Collagen types I, II, and III, Laminin, Decorin, E‑Cadherin, and Collectin molecules such as C1q. Platelet a2b1, also called GPIa, cooperates with GPVI to coordinate platelet collagen binding and activation. Adhesion is enhanced by crosstalk with Syndecan-1 or HGF R/c-Met and antagonized by crosstalk with Integrin alpha 1 beta 1. a2b1 is additionally expressed on select hematopoietic and non‑hematopoietic cells.

 

Showing 1-5 out of 5 Integrin alpha 2/CD49b Products

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Human Integrin  alpha 2/CD49b Antibody


Clone HAS3 was used by HLDA to establish CD designation
CyTOF-ready, Flow, ICC/IF, IPMAB12336  
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Mouse Integrin  alpha 2/CD49b Biotinylated Antibody

Flow, ICC/IF, WBBAF17401  
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Human Integrin  alpha 2/CD49b Biotinylated Antibody


Clone HAS3 was used by HLDA to establish CD designation
Flow, ICC/IF, IPBAM12331  
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Human Integrin  alpha 2/CD49b PE-conjugated Antibody


Clone HAS3 was used by HLDA to establish CD designation
FlowFAB1233P1  
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BTT 3033


Selective inhibitor of integrin α2β1
47241
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