Integrin alpha 2b beta 3: Products

Integrin alpha 2b beta 3, also known as GPIIbIIIa, is the most abundant Integrin expressed by megakaryocytes and platelets, both on the surface and within alpha granules. Deficiencies of alpha 2b beta 3 produce Glanzmann thrombasthenia, a potentially serious bleeding disorder. Active cell surface alpha 2b beta 3 adheres to Fibrinogen, mediating platelet/platelet interactions that initiate a cascade of platelet activation and aggregation, extracellular matrix adhesion, formation of thrombi, and clot retraction. It also binds matrix proteins that have an RGD motif, including Fibronectin, Plasminogen, Prothrombin, Thrombospondin, and Vitronectin.

 

Showing 1-4 out of 4 Integrin alpha 2b beta 3 Products

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Recombinant Human Integrin alpha 2b beta 3 Protein, CF

Bioactivity7148-A21  
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Eptifibatide


Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation
4725
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GR 144053 trihydrochloride


Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
1263
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Echistatin, α1 isoform


αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
32022
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