Integrin alpha 4 beta 1: Products

Integrin alpha 4 beta 1, also known as VLA-4, is an Integrin family adhesion receptor that shares the beta 1 subunit with eleven other family members and the alpha 4 subunit with Integrin alpha 4 beta 7. The noncovalent heterodimer of alpha 4/CD49d and beta 1/CD29 subunits mediates cell adhesion to VCAM-1/CD106 on other cells and the CS-1 fragment of Fibronectin in the extracellular matrix. Leukocytes (except for neutrophils), erythroid precursors, and some non-hematopoietic cells such as epicardial, endothelial and smooth muscle precursors, Schwann cells, and chorionic cells express a4b1. In the adult, a4b1 primarily regulates immune cell migration. Circulating leukocyte a4b1 is rapidly activated by inflamed endothelial cells that present VCAM-1 and chemokines such as CXCL12/SDF-1. This activation facilitates rolling, firm adhesion, and extravasation. During immune cell activation, a4b1 can function as a costimulatory molecule.

 

Showing 1-7 out of 7 Integrin alpha 4 beta 1 Products

page of 1
Results Per Page
DescriptionApplicationCat#CitationsImages 

Recombinant Human Integrin alpha 4 beta 1 Protein, CF

Bioactivity5668-A43  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

BIO 1211


Selective α4β1 (VLA-4) inhibitor
39102
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Recombinant Mouse Integrin alpha 4 beta 1 Protein, CF

Bioactivity6054-A41  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

BIO 5192


Highly potent and selective inhibitor of integrin α4β1
50511
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

LDV FITC


Fluorescent ligand for α4β1 (VLA-4)
4577
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

TCS 2314


α4β1 (VLA-4) antagonist
3900
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

R-BC154


High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs
6048
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page