JNK/c-jun Inhibitors: Products

Members of the MAPK family, the c-Jun N-terminal kinases (JNKs) are activated by environmental stresses and inflammatory cytokines. Ten JNK isoforms are created by alternative splicing of mRNA transcripts derived from three genes: JNK1, JNK2, and JNK3. All JNKs are activated by dual phosphorylation; at T183/Y185 for JNK1 and 2, and T221/Y223 for JNK3. Activated JNKs translocate to the nucleus where they regulate the activity of several transcription factors; including the c-Jun component of AP-1 and ATF-2.

Showing 1-13 out of 13 JNK/c-jun Inhibitors Products

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CEP 1347


Inhibitor of JNK signaling
4924
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SP 600125


Selective JNK inhibitor
149696
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TCS JNK 6o


Selective JNK inhibitor
3222
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c-JUN peptide


Peptide inhibitor of JNK/c-Jun interaction
19891
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AEG 3482


Inhibitor of JNK signaling
26512
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TCS JNK 5a


Selective inhibitor of JNK2 and JNK3
2827
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BI 78D3


Selective, competitive JNK inhibitor
33144
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SU 3327


Selective JNK inhibitor
36073
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IQ 3


Selective JNK3 inhibitor
45501
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SR 3576


Highly potent and selective JNK3 inhibitor
5044
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IQ 1S


JNK inhibitor; anti-inflammatory; also NO donor
5575
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JIP-1 (153-163)


JNK-selective inhibitor peptide
15651
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CC 401 dihydrochloride


High affinity JNK inhibitor; also inhibits HCMV replication
6258
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