Jagged 2: Products

Mammalian Jagged proteins are homologs of the Drosophila Notch ligand, Serrate, and together with Delta-like proteins, constitute ligands for the mammalian Notch proteins. Jagged 1 and 2 are 180 kDa and 150 kDa type I transmembrane glycoproteins, respectively, that possess extracellular DSL (delta, serrate, lag-2 consensus sequence) domains necessary for binding to Notch receptors, along with 15-16 calcium-binding EGF-like repeats which modulate the binding affinity. Jagged-Notch signaling specifies cell fate, regulates pattern formation, defines boundaries between different cell types, and modulates cell proliferation and differentiation, especially during hematopoiesis, myogenesis, neurogenesis and development of the vasculature. Since both the ligands and receptors are transmembrane proteins, direct cell-cell interactions are thought to be required for functional Notch signaling.

Showing 1-10 out of 10 Jagged 2 Products

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Recombinant Human Jagged 2 Fc Chimera Protein, CF

 1726-JG2  
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Human Jagged 2 Antibody

ICC/IF, IHC, WBAF17262  
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Human/Mouse Jagged 1/Jagged 2 APC-conjugated Antibody

FlowFAB1726A 
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Human/Mouse Jagged 1/Jagged 2 PE-conjugated Antibody

FlowFAB1726P 
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Mouse Jagged 2 PE-conjugated Antibody

FlowFAB4748P 
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Human Jagged 2 Biotinylated Antibody

WBBAF1726 
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Mouse Jagged 2 Antibody

FlowMAB4748 
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Mouse Jagged 2 APC-conjugated Antibody

FlowFAB4748A 
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Recombinant Mouse Jagged 2 Fc Chimera Protein, CF

 4748-JG 
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Human Jagged 2 (NP_002217) VersaClone cDNA

RDC0764 
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