Jak2: Products

Jak1, Jak 2, and Jak3 belong to the Janus Kinases family of protein tyrosine kinases that couple to cytokine receptors once activated by their corresponding ligands. Activation of Jak family members occurs via phosphorylation at two adjacent tyrosine residues as well as potentially one or more serine residues. Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites.

Jak1 is required for the activation of STAT1 and STAT2 in response to interferon. Jak2 plays an essential role in interferon gamma signaling. Also known as Leukocyte Janus Kinase (LJak), Jak3 is activated after binding to the gamma chain of Interleukin receptors, specifically the IL-2 and IL-4 receptors. Activation of Jak3 is associated with the rapid tyrosine phosphorylation of STAT proteins. Defects in Jak3 cause an autosomal severe combined immunodeficiency disease (SCID).

Showing 1-11 out of 11 Jak2 Products

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Mouse/Rat Jak2 Antibody

WBAF29881  
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AG 490


EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
041414
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Cucurbitacin I


Selective inhibitor of STAT3/JAK2 signaling
15717
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Lestaurtinib


JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB
33955
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CP 690550 citrate


Potent JAK inhibitor
45562
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1,2,3,4,5,6-Hexabromocyclohexane


Inhibits JAK2 autophosphorylation
22911
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SD 1008


JAK2/STAT3 signaling pathway inhibitor
3035
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NSC 33994


JAK2 inhibitor
43381
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Atiprimod dihydrochloride


JAK2 inhibitor
4580
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AZD 1480


Potent and selective JAK2 inhibitor; antiangiogenic
5617
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NVP BSK 805


Potent JAK2 inhibitor; orally bioavailable
5818
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