Jak3: Products

Jak1, Jak 2, and Jak3 belong to the Janus Kinases family of protein tyrosine kinases that couple to cytokine receptors once activated by their corresponding ligands. Activation of Jak family members occurs via phosphorylation at two adjacent tyrosine residues as well as potentially one or more serine residues. Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites.

Jak1 is required for the activation of STAT1 and STAT2 in response to interferon. Jak2 plays an essential role in interferon gamma signaling. Also known as Leukocyte Janus Kinase (LJak), Jak3 is activated after binding to the gamma chain of Interleukin receptors, specifically the IL-2 and IL-4 receptors. Activation of Jak3 is associated with the rapid tyrosine phosphorylation of STAT proteins. Defects in Jak3 cause an autosomal severe combined immunodeficiency disease (SCID).

Showing 1-8 out of 8 Jak3 Products

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Human Jak3 Antibody

Flow, ICC/IFMAB46991 
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CP 690550 citrate


Potent JAK inhibitor
45562  
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AG 490


EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
04148  
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Human Jak3 Antibody

WBMAB4699 
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TCS 21311


Potent JAK3 inhibitor. Also inhibits GSK-3beta and PKC
4221 
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ZM 449829


Potent, selective JAK3 inhibitor
13662  
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ZM 39923 hydrochloride


Potent, selective JAK3 inhibitor
13672  
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WHI-P 154


JAK3 kinase inhibitor. Also inhibits EGFR
3115 
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