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Klotho: Products

The Klotho proteins, Klotho and Klotho beta (beta KL), are type I transmembrane glycoproteins with extracellular regions that contain two beta-glycosidase-like repeats. Klotho has both membrane-bound and soluble forms; the soluble form predominates and consists of only the first beta-glycosidase-like repeat. Klotho has beta-glucuronidase activity against select steroid beta-glucuronides, appears to regulate calcium and vitamin D levels in serum, and is associated with premature aging.

Klotho beta, a divergent structural member of the glycosidase I superfamily, is primarily expressed in the liver and pancreas, with lower expression in adipose tissue. Klotho beta mediates the interaction of FGF-15 (human FGF-19) with FGF Receptor 4 in the liver, which negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes. Klotho beta is also a cofactor for the interaction of FGF-21 with FGF Receptor 1c in adipocytes. The expression pattern of Klotho beta suggests it may play a role in lipid metabolism.

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Mouse Klotho Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: IHC, WB
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AF1819

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Mouse Klotho Antibody Immunohistochemistry

Mouse Klotho Antibody

Clonality: Monoclonal
Host: Rat IgG2a Clone #236214
Applications: IHC, WB
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MAB1819

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Human Klotho Antibody

Clonality: Monoclonal
Host: Rat IgG2b Clone #775340
Applications: B/N
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MAB5334

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Human Klotho Antibody Neutralization

Mouse Klotho Biotinylated Antibody

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1 Citation
Clonality: Polyclonal
Host: Goat IgG
Applications: WB
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BAF1819

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