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LAP (TGF-beta 1): Products

Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.

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Recombinant Human LAP (TGF-beta 1) Protein

 246-LP12  
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Recombinant Human LAP (TGF-beta 1) Protein, CF

 246-LP/CF12  
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Human LAP (TGF-beta 1) Antibody

B/N, ICC/IF, SW, WBAF-246-NA10  
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Human LAP (TGF-beta 1) Antibody

B/N, ICC/IF, IHC, WBAB-246-NA3  
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Human LAP TGF-beta 1 Biotinylated Antibody

WBBAF2468  
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Human LAP TGF-beta 1 Biotinylated Antibody

BAM24623  
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Human LAP (TGF-beta 1) PE-conjugated Antibody

FlowFAB2463P4  
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Human LAP (TGF-beta 1) Quantikine ELISA Kit

ELISADLAP00 
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Human LAP (TGF-beta 1) Antibody

FlowMAB24635  
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Human LAP (TGF-beta 1) Antibody

B/NMAB2463  
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Human LAP (TGF-beta 1) APC-conjugated Antibody

FlowFAB2463A2  
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Human LAP (TGF-beta 1) Alexa Fluor® 488-conjugated Antibody

Flow, ICC/IFFAB2463G 
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Human LAP (TGF-beta 1) PerCP-conjugated Antibody

FlowFAB2463C1  
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Human LAP (TGF-beta 1) Antibody

MAB24611  
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Human LAP (TGF-beta 1) Alexa Fluor® 700-conjugated Antibody

FlowFAB2463N 
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Mouse LAP (TGF-beta 1) APC-conjugated Antibody

FlowFAB8118A 
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Mouse LAP (TGF-beta 1) PE-conjugated Antibody

FlowFAB8118P 
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Human LAP (TGF-beta 1) DuoSet ELISA

ELISADY246 
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Quantikine Immunoassay Control Set 788 Human LAP (TGF-b1)


For use with catalog number DLAP00
CtrlQC110 
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Proteome Profiler Human Adipokine Array Kit


Contains 4 membranes-each spotted in duplicate with 58 different obesity-related antibodies
ARY024 
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