LAP (TGF-beta 1): Products

TGF-beta 1 is expressed as a proprotein that is cleaved within the trans-Golgi to yield a latency-associated peptide (LAP) and the mature TGF-beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain noncovalently associated after secretion, forming the small latent TGF-beta 1 complex. Purified LAP can also associate with active TGF-beta and neutralize TGF-beta activity. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that can interact with the extracellular matrix. TGF-beta activation from latency is controlled by multiple factors including Plasmin, MMP-9, Thrombospondin-1, and various Integrins. The TGF-beta 1 LAP is capable of complexing with and inactivating all other human TGF-beta isoforms and those of most other species.

Showing 1-9 out of 9 LAP (TGF-beta 1) Products

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Human LAP (TGF-beta 1) PE-conjugated Antibody

FlowFAB2463P10  
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Human LAP TGF-beta 1 Biotinylated Antibody

BAM24623  
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Human LAP (TGF-beta 1) Antibody

B/N, ICC/IFMAB2463  
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Human LAP (TGF-beta 1) Antibody

CyTOF-ready, FlowMAB24636  
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Mouse LAP (TGF-beta 1) Antibody

CyTOF-ready, FlowMAB76664  
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Human LAP (TGF-beta 1) APC-conjugated Antibody

FlowFAB2463A3  
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Human LAP (TGF-beta 1) Alexa Fluor® 488-conjugated Antibody

Flow, ICC/IFFAB2463G1  
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Human LAP (TGF-beta 1) Antibody

MAB24611  
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Human LAP (TGF-beta 1) PerCP-conjugated Antibody

FlowFAB2463C1  
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