LAT: Products

LAT (Linker for Activation of T cells) is a type III transmembrane lipid raft protein that serves as a scaffold for signaling molecules. Upon T-cell antigen receptor activation, LAT is multiply phosphorylated by ZAP-70/Syk protein tyrosine kinases, creating docking sites for SH2 domain-containing proteins. For example, phospholipase C-gamma docks at Y161, which is pY132 in the short form. Mutation of this site results in a Th2 autoimmune lymphoproliferative disorder in mice.

Showing 1-10 out of 10 LAT Products

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Human LAT Antibody

CyTOF-ready, Flow, WBMAB63341 
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Human LAT Antibody

WBAF6208 
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Human Phospho-LAT (Y161) Antibody

WBMAB6334 
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Human LAT Alexa Fluor® 488-conjugated Antibody

FlowFAB63341G 
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Human LAT Alexa Fluor® 700-conjugated Antibody

FlowFAB63341N 
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Human LAT Alexa Fluor® 647-conjugated Antibody

FlowFAB63341R 
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Human LAT Alexa Fluor® 750-conjugated Antibody

FlowFAB63341S 
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Human LAT Alexa Fluor® 594-conjugated Antibody

FlowFAB63341T 
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Human LAT Alexa Fluor® 350-conjugated Antibody

FlowFAB63341U 
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Human LAT Alexa Fluor® 405-conjugated Antibody

FlowFAB63341V 
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