LYVE-1: Products

Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1 (LYVE-1) is a 60-kDa type I transmembrane glycoprotein that is a member of the Link Protein superfamily. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. It is often used as a marker of lymphatic endothelia.

LYVE-1 is expressed on both the lumenal and ablumenal surfaces of lymphatic endothelium, and also on hepatic blood sinusoidal endothelia. This expression pattern, combined with studies showing that LYVE-1 can support cellular HA internalization in vitro, may suggest LYVE-1 participation in HA internalization for degradation, or transport of HA from tissues into the lumen of lymphatic vessels. LYVE-1-directed HA localization to lymphatic surfaces might also affect aspects of the immune response or tumor metastases. HA binding to CD44 can still occur in the presence of LYVE-1 in vitro. Therefore, LYVE-1-directed HA localization to lymphatics could provide a substrate for transmigrating CD44+ leukocytes or tumor cells. In addition to hepatic and lymphatic endothelia, some expression of LYVE-1 has been reported on Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium. Roles for LYVE-1 on these cell and tissue types remain to be determined.

Showing 1-16 out of 16 LYVE-1 Products

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Mouse LYVE-1 Antibody

IHC, WBAF212520  
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Mouse LYVE-1 Antibody

B/N, Flow, ICC/IF, WBMAB212513  
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Human LYVE-1 Antibody

B/N, IHC, WBAF20896  
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Human LYVE-1 Antibody

Flow, IHC, WBMAB208921  
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Mouse LYVE-1 Biotinylated Antibody

IHC, WBBAF21253  
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Rat LYVE-1 Antibody

IHC, WBAF7939 
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Human LYVE-1 Biotinylated Antibody

ELISA(Det), IHC, WBBAF20891  
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Human LYVE-1 APC-conjugated Antibody

FlowFAB20892A2  
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Human LYVE-1 Antibody

ELISA(Cap), WBMAB20891 
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Mouse LYVE-1 Alexa Fluor® 488-conjugated Antibody

FlowFAB2125G1  
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Mouse LYVE-1 PE-conjugated Antibody

FlowFAB2125P 
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Mouse LYVE-1 APC-conjugated Antibody

FlowFAB2125A 
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Human LYVE-1 DuoSet ELISA

ELISADY20891  
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Recombinant Human LYVE-1 Protein, CF

 2089-LY 
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Recombinant Mouse LYVE-1 Protein, CF

 2125-LY 
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Human LYVE-1 Antibody

B/NMAB20893 
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