MAP3K8/Tpl2/COT: Products

MAP3K8, also called Tpl2 (tumor progression locus 2) or COT (Cancer Osaka Thyroid oncogene), is a cytosolic Ser/Thr kinase. MAP3K8 is one of the MAP kinase kinase (MAPKK) kinases that regulates the ERK1/ERK2 pathway in response to IL-1, facilitating IL-8 and MIP-1 beta production. MAP3K8 activates I kappa B kinases and induces the nuclear production of NF-kappa B.

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Human MAP3K8/Tpl2/COT Antibody

WBMAB4586 
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Recombinant Human Active MAP3K8/Tpl2/COT Protein, CF

 4586-KS 
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TC-S 7006


Potent and selective Tpl2 (Cot; MAP3K8) inhibitor
5240 
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