MDM2/HDM2: Products

MDM2 is a key regulator of p53 tumor suppressor protein activity and stability. MDM2 binds to and inhibits the transactivation domain of p53. In addition, MDM2 controls p53 stability by functioning as its E3 ligase in ubiquitination and by shuttling p53 from the nucleus to the cytoplasm for subsequent degradation. The importance of the p53/MDM2 relationship is underscored by the existence of an autoregulatory feedback loop whereby activated p53 transcriptionally upregulates the expression of its own inhibitor, MDM2.

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Human/Mouse/Rat MDM2/HDM2 Antibody

IHC, WBAF12445  
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Human MDM2/HDM2 Antibody

IPMAB1244 
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Recombinant Human GST-MDM2/HDM2 Protein, CF

 E3-202 
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Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate

K-200B 
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Human/Mouse/Rat MDM2/HDM2 Biotinylated Antibody

WBBAF1244 
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Recombinant Human MDM2/HDM2 Protein, CF

 E3-204 
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NSC 66811


MDM2 antagonist. Disrupts MDM2-p53 interaction
2936 
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HLI 373


Hdm2 inhibitor; activates p53-dependent transcription
3503 
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Human Total MDM2/HDM2 DuoSet IC ELISA

ELISADYC1244-2 
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Human MDM2/S5a Ubiquitination Kit

K-210 
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