MEK1/MEK2: Products

MEK1 and MEK2, also known as MAP2K1 and MAP2K2, are activated in response to mitogenic stimuli. Activation occurs through dual phosphorylation at S218/S222 of MEK1 and S222/S226 of MEK2 by several upstream MAP3Ks. Both MEK1 and MEK2 are dual-specificity protein kinases, phosphorylating and activating ERK1 and ERK2 at Thr and Tyr positions.

Showing 1-8 out of 8 MEK1/MEK2 Products

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PD 0325901


Potent inhibitor of MEK1/2
419216
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U0126


Potent, selective inhibitor of MEK1 and 2
1144114
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PD 98059


MEK inhibitor
121383
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Arctigenin


Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
17772
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U0124


Inactive analog of U0126 (Cat. No. 1144)
18689
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SL 327


Selective inhibitor of MEK1 and MEK2; brain penetrant
196917
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PD 198306


Selective inhibitor of MEK1/2
26051
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PD 184352


Selective MEK inhibitor
42373
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