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NFkB/IkB Inhibitors: Products

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.

Showing 1-44 out of 44 NFkB/IkB Inhibitors Products

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MG 132


Proteasome and calpain inhibitor. Inhibits NF-κB activation
174843
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Caffeic acid phenethyl ester


Specific inhibitor of NF-κB activation
27437
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Triptolide


Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
32532
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TPCA-1


Potent, selective inhibitor of IKKβ
25598
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Luteolin


Anti-inflammatory, antioxidant and free radical scavenger
28741
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Pyrrolidinedithiocarbamate ammonium


Inhibits NF-κB, prevents increase in NOS mRNA
07277
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Bay 11-7085


Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
17434
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Bay 11-7821


E2 ubiquitin (Ub) conjugating enzymes inhibitor
17446
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Arctigenin


Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
17772
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PR 39 (porcine)


IκBα inhibitor
19471
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IKK 16


Selective inhibitor of IKK
25396
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Celastrol


Inhibits TNF-α-induced NF-κB activation
32031
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ACHP


Selective IKKα and IKKβ inhibitor
45473
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Honokiol


Blocks NF-κB activation; also anti-inflammatory and antioxidant
4590
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BMS 345541


Selective allosteric inhibitor of IKK; anti-inflammatory
4806
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Amlexanox


Selective inhibitor of TBK
48571
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Bengamide B


Potent inhibitor of NF-κB activation
5273
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SP 100030


NF-κB and AP-1 dual inhibitor
5309
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RAGE antagonist peptide


RAGE antagonist
6259
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10Z-Hymenialdisine


Pan kinase inhibitor; potently inhibits MEK1
1532
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Piceatannol


Inhibits TNF-induced NF-κB activation
15546
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Ro 106-9920


Inhibitor of NF-κB activation
17782
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Cardamonin


Inhibitor of NF-κB activation; anti-inflammatory
25092
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IMD 0354


Inhibitor of IKKβ
26114
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Gliotoxin


Inhibitor of 20S proteasome; immunosuppressant
2637
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Withaferin A


Inhibits NF-κB activation
28165
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HU 211


NMDA receptor antagonist; also NF-κB inhibitor. Restrictions apply. See special conditions on product page.
2861
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SC 514


IKKβ inhibitor; attenuates NF-κB-induced gene expression
33182
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Pristimerin


Potent, reversible MAGL inhibitor
3731
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PSI


Proteasome inhibitor. Also prevents activation of NF-κB
4045
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PF 184


Potent and selective IKKβ inhibitor
42381
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CID 2858522


Selectively inhibits PKC-induced NF-κB activation
42461
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ML 130


Inhibits NOD1-induced NF-κB activation
4354
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Tanshinone IIA


Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties
44261
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Andrographolide


Inhibits NFκB; blocks androgen receptor (AR) expression
4626
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ML 120B dihydrochloride


Novel IKK2-selective inhibitor
4899
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Sulfasalazine


Inhibitor of NF-κB activation; also inhibits SXC
49351
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IP7e


Potent Nurr1 activator
5699
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BI 605906


Selective IKKβ inhibitor
5300
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GSK 319347A


Potent and selective IKKε inhibitor
5672
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C-DIM 12


Nurr1 activator; inhibits NF-κB-dependent gene expression
5821
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IT 901


NF-κB c-Rel subunit inhibitor
5846
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Zoledronic Acid


Potent farnesyl diphosphate (FPP) synthase inhibitor
6111
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FPS ZM1


High affinity antagonist of RAGE
6237
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