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NFkB1: Products

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.

Showing 1-25 out of 25 NFkB1 Products

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DescriptionApplicationCat#CitationsImages 

MG 132


Proteasome and calpain inhibitor. Inhibits NF-kappaB activation
174833  
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Sulfasalazine


Inhibitor of NF-kappaB activation; also inhibits SXC
49351  
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Triptolide


Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
32532  
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Caffeic acid phenethyl ester


Specific inhibitor of NF-kappaB activation
27437  
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Human/Mouse NF kappa B1 Antibody

ChIP, WBAF2697 
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Betulinic acid


Antitumor and anti-HIV agent; activates NF-kappaB. Also TGR5 agonist
39061  
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Human NF kappa B1 Antibody

WBMAB26971  
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Gliotoxin


Inhibitor of 20S proteasome; immunosuppressant
2637 
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Withaferin A


Inhibits NF-kappaB activation
28164  
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Pyrrolidinedithiocarbamate ammonium


Inhibits NF-kappaB, prevents increase in NOS mRNA
07275  
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Cardamonin


Inhibitor of NF-kappaB activation; anti-inflammatory
25092  
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SP 100030


NF-kappaB and AP-1 dual inhibitor
5309 
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Ro 106-9920


Inhibitor of NF-kappaB activation
17782  
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Piceatannol


Inhibits TNF-induced NF-kappaB activation
15545  
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Celastrol


Inhibits TNF-alpha-induced NF-kappaB activation
32031  
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CID 2858522


Selectively inhibits PKC-induced NF-kappaB activation
4246 
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PSI


Proteasome inhibitor. Also prevents activation of NF-kappaB
4045 
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Honokiol


Blocks NF-kappaB activation; also anti-inflammatory and antioxidant
4590 
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Andrographolide


Inhibits NFkappaB; blocks androgen receptor (AR) expression
4626 
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Tanshinone IIA


Inhibits NF-kappaB and AP-1 DNA binding. Displays antioxidant properties
4426 
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Bengamide B


Potent inhibitor of NF-kappaB activation
5273 
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Prostratin


PKC activator; also NF-kappaB activator
5739 
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HU 211


NMDA receptor antagonist; also NF-kappaB inhibitor. Restrictions apply. See special conditions on product page.
2861 
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Proteome Profiler Human Cell Stress Array Kit


Contains 4 membranes - each spotted in duplicate with 26 different cell stress antibodies
ARY0182  
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Proteome Profiler Human NFkB Pathway Array Kit


Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies
ARY029 
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