NFkB2: Products

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.

Showing 1-21 out of 21 NFkB2 Products

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MG 132


Proteasome and calpain inhibitor. Inhibits NF-κB activation
174843
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Caffeic acid phenethyl ester


Specific inhibitor of NF-κB activation
27437
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Triptolide


Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
32532
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Pyrrolidinedithiocarbamate ammonium


Inhibits NF-κB, prevents increase in NOS mRNA
07277
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Celastrol


Inhibits TNF-α-induced NF-κB activation
32031
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Honokiol


Blocks NF-κB activation; also anti-inflammatory and antioxidant
4590
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Bengamide B


Potent inhibitor of NF-κB activation
5273
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SP 100030


NF-κB and AP-1 dual inhibitor
5309
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Prostratin


PKC activator; also NF-κB activator
5739
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Piceatannol


Inhibits TNF-induced NF-κB activation
15546
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Ro 106-9920


Inhibitor of NF-κB activation
17782
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Cardamonin


Inhibitor of NF-κB activation; anti-inflammatory
25092
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Gliotoxin


Inhibitor of 20S proteasome; immunosuppressant
2637
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Withaferin A


Inhibits NF-κB activation
28165
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HU 211


NMDA receptor antagonist; also NF-κB inhibitor. Restrictions apply. See special conditions on product page.
2861
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Betulinic acid


Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
39061
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PSI


Proteasome inhibitor. Also prevents activation of NF-κB
4045
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CID 2858522


Selectively inhibits PKC-induced NF-κB activation
42461
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Tanshinone IIA


Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties
44261
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Andrographolide


Inhibits NFκB; blocks androgen receptor (AR) expression
4626
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Sulfasalazine


Inhibitor of NF-κB activation; also inhibits SXC
49351
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