Nicastrin: Products

Nicastrin (NCT) is a 150 - 160 kDa member of the nicastrin family of proteins. It is a component of the aspartyl protease γ-secretase complex and serves to stabilize and direct γ-secretase components to proper positions in the plasma membrane. The γ-secretase complex mediates the cleavage of intramembrane proteins such as notch-1 and APP. Mature human nicastrin is a 676 amino acid type I transmembrane glycoprotein. It contains a 636 aa extracellular domain (aa 34 - 669) that shows a 58 aa sequence (aa 312 - 369) which interacts with γ-secretase substrates. There are multiple splice variants of nicastrin. Over aa 34 - 669, human nicastrin shares 90% aa identity with mouse nicastrin.

Showing 1-4 out of 4 Nicastrin Products

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Human Nicastrin Isoform 1 Antibody

IHC, WBAF5378 
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Human Nicastrin Antibody

WBMAB53781 
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Human Nicastrin Isoform 1 Biotinylated Antibody

WBBAF5378 
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Human Nicastrin Antibody

ICC/IFMAB5378 
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