Nicotinic Acetylcholine R alpha 1/CHRNA1: Products

The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits. CHRNA1 is an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus. Defects in CHRNA1 are a cause of multiple pterygium syndrome lethal type (MUPSL). Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome.

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α-Conotoxin EI


alpha1beta1deltagamma selective nAChR antagonist
3124 
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Human nAChR alpha 1/CHRNA1 (NP_000070) VersaClone cDNA

RDC0279 
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Human nAChR alpha 1/CHRNA1 (P02708) VersaClone cDNA

RDC0280 
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