Nitric Oxide: Products

Nitric Oxide (NO) is a gaseous free radical with a short half-life in vivo of a few seconds or less. It is a pleiotropic biological mediator that regulates diverse activities ranging from neuronal function to immune system regulation. NO is catalyzed by enzymes of the Nitric Oxide Synthase (NOS) family, which include neuronal NOS (nNOS/NOS1), inducible NOS (iNOS/NOS2), and endothelial NOS (eNOS/NOS3). NO is lipid soluble, so it is not stored by synthesized de novo and freely diffuses across lipid membranes. NO mediates its effects on target cells via several different mechanisms. For instance, NO can activate Guanylyl Cyclase, which catalyzes the formation of the second messenger cGMP. cGMP is implicated with a range of biological functions such as regulating smooth muscle contractility, cell survival, proliferation, axon guidance, synaptic plasticity, inflammation, angiogenesis, and the activity of cyclic nucleotide-gated channels. NO also functions as an anti-tumor and anti-microbial agent via mechanisms that include its conversion to peroxynitrite, the formation of S-nitrosothiols, and the depletion of arginine. Additionally, NO suppresses mitochondrial respiration through the inhibition of Cytochrome Oxidase, and may modify protein activity through post-translational nitrosylation. Altered levels of NO have been shown to be associated with sepsis, reproduction, infection, hypertension, exercise, type 2 diabetes, hypoxia, and cancer.

Showing 1-14 out of 14 Nitric Oxide Products

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Total Nitric Oxide and Nitrate/Nitrite Parameter Assay Kit

ELISAKGE00143  
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SNAP


A stable analog of endogenous S-nitroso compounds
05986  
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Diphenyleneiodonium chloride


GPR3 agonist; also inhibits NOS and NADPH oxidases
05044  
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Parameter Immunoassay Control Set 849 for Nitrate


For use with catalog numbers KGE001, SKGE001, PKGE001
CtrlQC134 
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Parameter Immunoassay Control Set 677 for Nitrite


For use with catalog numbers KGE001, SKGE001, PKGE001
CtrlQC135 
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SNOG


NO carrier. Breaks down to release NO
0603 
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L-Arginine


Endogenous substrate for NOS
06631  
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N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide


Nitroxyl precursor
0722 
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SIN-1 chloride


Water-soluble NO donor
0756 
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Carboxy-PTIO, potassium salt


Stable, water-soluble deactivator of NO
07728  
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Spermine NONOate


Slow NO releasing agent
11351  
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FK 409


NO donor
3105 
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DMPO


Nitric oxide spin trap; measure oxygen-centered free radicals
3415 
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DETA NONOate


Nitric oxide donor
6077 
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