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Notch-1: Products

Notch proteins (so named for 'notches' in fly wings) are type I transmembrane glycoproteins involved in specifying cell fates and defining boundaries between different cell types during developmental processes. Notch extracellular domains are large, having 34-36 EGF-like repeats followed by three notch/Lin-12 repeats. Notch proteins interact with transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand binding, a series of cleavage events results in the release of the Notch intracellular domain (NICD), which translocates to the nucleus and initiates transcription of Notch-responsive genes. Thus, Notch acts as both a ligand-binding receptor and a nuclear factor that regulates transcription.

The four mammalian Notch receptors appear to have distinct functions, since they do not compensate for one another in genetic studies. Mutations in Notch receptors also lead to specific developmental disorders. For example, Notch-3 is predominantly expressed in the developing central nervous system of mice. Mutations in Notch-3 in humans cause an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). This disorder is characterized by recurrent ischemic strokes at an early age without any underlying vascular risk and progressive dementia.

Showing 1-21 out of 21 Notch-1 Products

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Mouse/Rat Notch-1 Antibody

B/N, Flow, ICC/IF, IHC, WBAF1057 
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Human Notch-1 Intracellular Domain Antibody

ChIP, Flow, ICC/IF, WBAF3647 
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Recombinant Human Notch-1 Fc Chimera Protein, CF

 3647-TK 
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Human Notch-1 Antibody

ELISA(Cap), FlowMAB5317 
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Mouse Notch-1 Antibody

IHC, WBAF5267 
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Human Notch-1 PE-conjugated Antibody

FlowFAB5317P 
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Human Notch-1 Antibody

WBAF5317 
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Recombinant Rat Notch-1 Fc Chimera Protein, CF

 1057-TK 
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Mouse Notch-1 Biotinylated Antibody

WBBAF5267 
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Human Notch-1 Biotinylated Antibody

WBBAF5317 
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Human Notch-1 APC-conjugated Antibody

FlowFAB5317A 
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Human Notch-1 Biotinylated Antibody

BAM53171 
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Mouse Notch-1 PerCP-conjugated Antibody

FlowIC5267C 
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Rat Notch-1 Biotinylated Antibody

WBBAF1057 
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Human Notch-1 Intracellular Domain Antibody

ICC/IF, WBMAB3647 
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Human Notch-1 Intracellular Domain Biotinylated Antibody

WBBAF3647 
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Mouse Notch-1 PE-conjugated Antibody

FlowIC5267P 
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Mouse Notch-1 Antibody

FlowMAB5267 
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Human Notch-1 DuoSet ELISA

ELISADY5317 
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Recombinant Mouse Notch-1 Fc Chimera Protein, CF

 5267-TK 
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Proteome Profiler Human sReceptor Array, Non-hematopoietic


Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
ARY012 
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