Notch-2: Products

Notch proteins (so named for notches in fly wings) are type I transmembrane glycoproteins involved in specifying cell fates and defining boundaries between different cell types during developmental processes. Notch extracellular domains are large, having 34-36 EGF-like repeats followed by three notch/Lin-12 repeats. Notch proteins interact with transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand binding, a series of cleavage events results in the release of the Notch intracellular domain (NICD), which translocates to the nucleus and initiates transcription of Notch-responsive genes. Thus, Notch acts as both a ligand-binding receptor and a nuclear factor that regulates transcription.

The four mammalian Notch receptors appear to have distinct functions, since they do not compensate for one another in genetic studies. Mutations in Notch receptors also lead to specific developmental disorders. For example, Notch-3 is predominantly expressed in the developing central nervous system of mice. Mutations in Notch-3 in humans cause an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). This disorder is characterized by recurrent ischemic strokes at an early age without any underlying vascular risk and progressive dementia.

Showing 1-15 out of 15 Notch-2 Products

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Rat Notch-2 Antibody

B/N, Flow, IHC, WBAF1190 
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Human Notch-2 Intracellular Domain Antibody

IHC, WBAF37351  
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Recombinant Human Notch-2 Fc Chimera Protein, CF

 3735-NT 
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Mouse/Rat Notch-2 Antibody

WBAF5196 
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Rat Notch-2 Biotinylated Antibody

Flow, WBBAF1190 
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Rat Notch-2 Antibody

WBMAB1190 
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Mouse Notch-2 PE-conjugated Antibody

FlowFAB5196P 
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Human Notch-2 APC-conjugated Antibody

FlowFAB37351A 
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Human Notch-2 Intracellular Domain Biotinylated Antibody

WBBAF3735 
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Mouse Notch-2 Antibody

FlowMAB5196 
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Human Notch-2 Intracellular Domain Antibody

WBMAB3735 
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Mouse Notch-2 APC-conjugated Antibody

FlowFAB5196A 
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Human Notch-2 Antibody

FlowMAB37351 
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Recombinant Mouse Notch-2 Fc Chimera Protein, CF

 5196-NT 
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Recombinant Rat Notch-2 Fc Chimera Protein, CF

 1190-NT 
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