Notch-1: Products

Notch proteins (so named for 'notches' in fly wings) are type I transmembrane glycoproteins involved in specifying cell fates and defining boundaries between different cell types during developmental processes. Notch extracellular domains are large, having 34-36 EGF-like repeats followed by three notch/Lin-12 repeats. Notch proteins interact with transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand binding, a series of cleavage events results in the release of the Notch intracellular domain (NICD), which translocates to the nucleus and initiates transcription of Notch-responsive genes. Thus, Notch acts as both a ligand-binding receptor and a nuclear factor that regulates transcription.

The four mammalian Notch receptors appear to have distinct functions, since they do not compensate for one another in genetic studies. Mutations in Notch receptors also lead to specific developmental disorders. For example, Notch-3 is predominantly expressed in the developing central nervous system of mice. Mutations in Notch-3 in humans cause an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). This disorder is characterized by recurrent ischemic strokes at an early age without any underlying vascular risk and progressive dementia.

Showing 1-29 out of 29 Notch-1 Products

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Mouse/Rat Notch-1 Antibody

B/N, CyTOF-ready, Flow, ICC/IF, IHC, WBAF10573  
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Human Notch-1 Intracellular Domain Antibody

ChIP, CyTOF-ready, Flow, ICC/IF, WBAF36473  
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Mouse Notch-1 Antibody

IHC, WBAF52671  
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Human Notch-1 Antibody

CyTOF-ready, ELISA(Cap), FlowMAB53171  
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Human Notch-1 PE-conjugated Antibody

FlowFAB5317P1  
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Human Notch-1 Antibody

WBAF5317 
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Mouse Notch-1 Antibody

CyTOF-ready, FlowMAB5267 
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Rat Notch-1 Biotinylated Antibody

WBBAF1057 
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Human Notch-1 Intracellular Domain Biotinylated Antibody

WBBAF3647 
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Mouse Notch-1 Biotinylated Antibody

WBBAF5267 
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Human Notch-1 Biotinylated Antibody

WBBAF5317 
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Human Notch-1 Biotinylated Antibody

BAM53171 
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Human Notch-1 APC-conjugated Antibody

FlowFAB5317A 
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Human Notch-1 Intracellular Domain Antibody

ICC/IF, WBMAB3647 
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Mouse Notch-1 PE-conjugated Antibody

FlowIC5267P 
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Mouse Notch-1 Alexa Fluor® 488-conjugated Antibody

FlowFAB5267G 
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Mouse Notch-1 Alexa Fluor® 700-conjugated Antibody

FlowFAB5267N 
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Mouse Notch-1 Alexa Fluor® 647-conjugated Antibody

FlowFAB5267R 
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Mouse Notch-1 Alexa Fluor® 750-conjugated Antibody

FlowFAB5267S 
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Mouse Notch-1 Alexa Fluor® 594-conjugated Antibody

FlowFAB5267T 
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Mouse Notch-1 Alexa Fluor® 350-conjugated Antibody

FlowFAB5267U 
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Mouse Notch-1 Alexa Fluor® 405-conjugated Antibody

FlowFAB5267V 
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Human Notch-1 Alexa Fluor® 488-conjugated Antibody

FlowFAB5317G 
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Human Notch-1 Alexa Fluor® 700-conjugated Antibody

FlowFAB5317N 
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Human Notch-1 Alexa Fluor® 647-conjugated Antibody

FlowFAB5317R 
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Human Notch-1 Alexa Fluor® 750-conjugated Antibody

FlowFAB5317S 
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Human Notch-1 Alexa Fluor® 594-conjugated Antibody

FlowFAB5317T 
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Human Notch-1 Alexa Fluor® 350-conjugated Antibody

FlowFAB5317U 
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Human Notch-1 Alexa Fluor® 405-conjugated Antibody

FlowFAB5317V 
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