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Notch-1: Products

Notch proteins (so named for 'notches' in fly wings) are type I transmembrane glycoproteins involved in specifying cell fates and defining boundaries between different cell types during developmental processes. Notch extracellular domains are large, having 34-36 EGF-like repeats followed by three notch/Lin-12 repeats. Notch proteins interact with transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand binding, a series of cleavage events results in the release of the Notch intracellular domain (NICD), which translocates to the nucleus and initiates transcription of Notch-responsive genes. Thus, Notch acts as both a ligand-binding receptor and a nuclear factor that regulates transcription.

The four mammalian Notch receptors appear to have distinct functions, since they do not compensate for one another in genetic studies. Mutations in Notch receptors also lead to specific developmental disorders. For example, Notch-3 is predominantly expressed in the developing central nervous system of mice. Mutations in Notch-3 in humans cause an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). This disorder is characterized by recurrent ischemic strokes at an early age without any underlying vascular risk and progressive dementia.

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Mouse/Rat Notch‑1 Antibody

2 Citations
Clonality: Polyclonal
Host: Goat IgG
Applications: WB, Flow, ICC/IF, B/N, IHC
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AF1057

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Notch-1 in Rat Cortical Stem Cells.
Notch-1 in Mouse Cortical Stem Cells.
Notch-1 in Rat Embryo.

Human Notch‑1 Intracellular Domain Antibody

Clonality: Polyclonal
Host: Sheep IgG
Applications: WB, ICC/IF, ChIP, Flow
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AF3647

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Detection of Human Notch-1.<BR>
Notch&#x2011;1 in Saos-2 Human Cell Line.
Detection of Notch&#x2011;1-regulated Genes by Chromatin Immunoprecipitation.

Human Notch‑1 Antibody

1 Citation
Clonality: Monoclonal
Host: Mouse IgG1 Clone #527425
Applications: Flow
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MAB5317

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Detection of Notch-1 in U2OS Human Cell Line by Flow Cytometry.

Mouse Notch‑1 Antibody

Clonality: Polyclonal
Host: Sheep IgG
Applications: IHC, WB
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AF5267

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Detection of Mouse Notch&#x2011;1 by Western Blot.
Notch-1 in Mouse Neural Tube.

Human Notch‑1 Antibody

Clonality: Polyclonal
Host: Sheep IgG
Applications: WB
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AF5317

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Detection of Human Notch&#x2011;1 by Western Blot.

Mouse Notch‑1 Antibody

Clonality: Monoclonal
Host: Mouse IgG1 Clone #N1A
Applications: Flow
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MAB5267

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Detection of Notch&#x2011;1 in RPMI&#160;8226 Human Cell Line by Flow Cytometry.

Human Notch‑1 Intracellular Domain Antibody

Clonality: Monoclonal
Host: Mouse IgG2a Clone #433802
Applications: ICC/IF, WB
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MAB3647

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Human Notch‑1 PE‑conjugated Antibody

1 Citation
Clonality: Monoclonal
Host: Mouse IgG1 Clone #527425
Applications: Flow
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FAB5317P

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<P align=left>Detection of Notch-1 in U2OS Human Cell Line by Flow Cytometry.

Human Notch‑1 Biotinylated Antibody

Clonality: Polyclonal
Host: Sheep IgG
Applications: WB
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BAF5317

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Rat Notch‑1 Biotinylated Antibody

Clonality: Polyclonal
Host: Goat IgG
Applications: WB
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BAF1057

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