Notch-3: Products

Notch proteins (so named for 'notches' in fly wings) are type I transmembrane glycoproteins involved in specifying cell fates and defining boundaries between different cell types during developmental processes. Notch extracellular domains are large, having 34-36 EGF-like repeats followed by three notch/Lin-12 repeats. Notch proteins interact with transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand binding, a series of cleavage events results in the release of the Notch intracellular domain (NICD), which translocates to the nucleus and initiates transcription of Notch-responsive genes. Thus, Notch acts as both a ligand-binding receptor and a nuclear factor that regulates transcription.

The four mammalian Notch receptors appear to have distinct functions, since they do not compensate for one another in genetic studies. Mutations in Notch receptors also lead to specific developmental disorders. For example, Notch-3 is predominantly expressed in the developing central nervous system of mice. Mutations in Notch-3 in humans cause an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). This disorder is characterized by recurrent ischemic strokes at an early age without any underlying vascular risk and progressive dementia.

Showing 1-17 out of 17 Notch-3 Products

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Recombinant Human Notch-3 (aa 40-467) Fc Chimera Protein, CF

 1559-NT2  
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Mouse Notch-3 Antibody

B/N, CyTOF-ready, Flow, IHC, WBAF13081  
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Human Notch-3 Antibody

CyTOF-ready, FlowMAB15591  
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Human Notch-3 Antibody

B/N, WBAF15592  
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Mouse Notch-3 Biotinylated Antibody

IHC, WBBAF1308 
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Recombinant Mouse Notch-3 Fc Chimera Protein, CF

 1308-NT 
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Human Notch-3 Biotinylated Antibody

WBBAF1559 
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Human Notch-3 APC-conjugated Antibody

FlowFAB6870A 
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Human Notch-3 PE-conjugated Antibody

FlowFAB6870P 
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Human Notch-3 APC-conjugated Antibody

FlowFAB1559A 
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Human Notch-3 Alexa Fluor® 488-conjugated Antibody

FlowFAB1559G 
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Human Notch-3 Alexa Fluor® 700-conjugated Antibody

FlowFAB1559N 
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Human Notch-3 Alexa Fluor® 647-conjugated Antibody

FlowFAB1559R 
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Human Notch-3 Alexa Fluor® 750-conjugated Antibody

FlowFAB1559S 
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Human Notch-3 Alexa Fluor® 594-conjugated Antibody

FlowFAB1559T 
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Human Notch-3 Alexa Fluor® 350-conjugated Antibody

FlowFAB1559U 
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Human Notch-3 Alexa Fluor® 405-conjugated Antibody

FlowFAB1559V 
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