Nrf2 Modulators: Products

NF-E2 related factor 2 (Nrf2) is a member of the cap 'n collar family of basic leucine zipper transcription factors. By binding antioxidant response elements (AREs), Nrf2 activates the transcription of genes encoding antioxidant and phase II drug-metabolizing enzymes needed to protect cells against oxidative damage. Transcriptional targets regulated by Nrf2 include genes encoding glutathione S-transferases, superoxide dismutase-1, and heme oxygenase-1.

Showing 1-11 out of 11 Nrf2 Modulators Products

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CDDO Im


Nrf2 signaling activator
4737 
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Curcumin


Antitumor, anti-inflammatory and antioxidant
28411  
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MMF


Activator of Nrf2 pathway; primary metabolite of DMF (Cat. No. 4512)
4511 
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DMF


Nrf2 pathway activator; neuroprotective
4512 
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Andrographolide


Inhibits NFκB; blocks androgen receptor (AR) expression
4626 
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TAT 14


Nrf2 pathway activator; blocks Nrf2/Keap1 interaction
4811 
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AI-3


ARE activator; induces Nrf2-ARE-dependent transcription
5145 
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NK 252


Nrf2 activator
5293 
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Oltipraz


Nrf2 activator
5294 
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RA 839


Nrf2 activator; inhibits Nrf2/Keap1 interaction
5707 
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ML 334


Inhibitor of Keap1- Nrf2 interaction
5625 
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