Nucleoredoxin: ProductsNucleoredoxin (NRX; also known as NXN and Red-1) is a 51-55 kDa member of the thioredoxin (TXR) family of proteins. It is widely expressed, and exists in both the nucleus and cytoplasm of cells where it regulates two pathways. In the nucleus, NRX may act as a transcription factor in the Wnt-pathway; a stable (reduced) NRX binds to DVL, thereby blocking downstream Wnt/beta-Catenin signaling. It also binds to PP2A subunits PP2AC and PP2AA, generating an active PP2A complex. Human NRX is 435 amino acids (aa) in length and contains a TXR domain (aa 167-321) that shows a WCPPC catalytic site, and a substrate recognition PDI-b' region (aa 312-427). There are three potential isoform variants. Over amino acids 131-435, human NRX shares 99% aa identity with mouse NRX.