OX2 Receptor Antagonists: Products

Hypocretin receptor 2 (HCRTR2); also known as orexin receptor 2 or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. HCRTR2 also influences reward circuits involving food or addictive drugs. The extracellular portions of human HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat HCRTR2, respectively.

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TCS OX2 29


Potent and selective OX2 antagonist
33712  
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EMPA


Highly potent and selective OX2 antagonist; brain penetrant
45581  
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JNJ 10397049


Selective OX2 receptor antagonist
4317 
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