Orexin B/Hypocretin-2: Products

Orexin A and orexin B are neuropeptide hormones derived from proteolytic processing of the same orexin precursor protein. Orexins are named for their orexigenic-inducing (orexis; Greek for appetite) activity. They are released from the hypothalamus and are involved in the regulation of sleeping patterns, feeding, and metabolism. Orexins A and B are less than 50% amino acid identical. Orexin A is a ligand for two 7-transmembrane orexin receptors, OX1R and OX2R, while orexin B preferentially binds OX2R. Defects in the orexin precursor are a cause of narcolepsy in humans.

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Human Orexin B/Hypocretin-2 Antibody

IHCMAB734 
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Orexin B (human)


Endogenous agonist at OX1 and OX2
14562  
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Orexin B (mouse)


Endogenous agonist at OX1 and OX2
14572  
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