Orexin R2/HCRTR2: Products

Hypocretin receptor 2 (HCRTR2); also known as orexin receptor 2 or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. HCRTR2 also influences reward circuits involving food or addictive drugs. The extracellular portions of human HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat HCRTR2, respectively.

Showing 1-12 out of 12 Orexin R2/HCRTR2 Products

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TCS OX2 29


Potent and selective OX2 antagonist
33712  
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Human Orexin R2/HCRTR2 Antibody

FlowMAB5246 
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Human/Mouse Orexin R2/HCRTR2 APC-conjugated Antibody

FlowIC5246A 
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Human/Mouse Orexin R2/HCRTR2 PE-conjugated Antibody

FlowIC5246P 
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Human Orexin R2/HCRTR2 Antibody

IHCMAB52461 
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[Ala11,D-Leu15]-Orexin B


Potent, selective OX2 receptor agonist
21424  
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TCS 1102


Potent, dual orexin receptor antagonist
38182  
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EMPA


Highly potent and selective OX2 antagonist; brain penetrant
45581  
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ACT 462206


Potent, dual orexin receptor antagonist
5319 
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JNJ 10397049


Selective OX2 receptor antagonist
4317 
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Human Orexin R2/HCRTR2 (AAC39602) VersaClone cDNA

RDC0522 
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Mouse Orexin R2/HCRTR2 (NP_945200) VersaClone cDNA

RDC0617 
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