P2X7/P2RX7: Products

P2RX7 belongs to the family of purinoceptors for ATP. It functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. P2RX7 antagonists have emerged as novel therapeutics for the treatment of acute inflammation, pain and fever, with wider anti-inflammatory activity than currently used cyclooxygenase inhibitors.

Showing 1-11 out of 11 P2X7/P2RX7 Products

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BzATP triethylammonium salt


Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist
33125  
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KN-62


Non-competitive P2X7 antagonist
127715  
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A 438079 hydrochloride


Competitive P2X7 antagonist
297228  
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A 740003


Potent and selective P2X7 antagonist
37016  
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A 804598


Potent and selective P2X7 antagonist
44731  
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AZ 10606120 dihydrochloride


Potent P2X7 receptor antagonist
33239  
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AZ 11645373


Potent and selective human P2X7 antagonist
33174  
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JNJ 47965567


Potent and selective P2X7 antagonist; brain penetrant
5299 
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GW 791343 hydrochloride


P2X7 allosteric modulator
3385 
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A 839977


Potent P2X7 antagonist
42321  
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Human P2RX7 (AAH11913) VersaClone cDNA

RDC0486 
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