PD-L2/B7-DC: Products

PD-L2 (Programmed Death Ligand 2), also known as B7-DC and butyrophilin-like protein, is a transmembrane protein expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites, PD-L2 is upregulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand upregulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.

Showing 1-20 out of 20 PD-L2/B7-DC Products

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Recombinant Human PD-L2/B7-DC Fc Chimera Protein, CF

 1224-PL2  
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Human PD-L2/B7-DC Antibody

Flow, IHC, WBMAB12243  
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Mouse PD-L2/B7-DC Antibody

B/N, Flow, IHC, WBAF10222  
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Recombinant Mouse PD-L2/B7-DC Fc Chimera Protein, CF

 1022-PL1  
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Human PD-L2/B7-DC Antibody

B/N, IHC, WBAF12241  
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Mouse PD-L2/B7-DC Biotinylated Antibody

IHC, WBBAF1022 
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Mouse PD-L2/B7-DC Antibody

Flow, WBMAB1022 
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Human PD-L2/B7-DC PE-conjugated Antibody

FlowFAB1224P 
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Recombinant Mouse PD-L2/B7-DC His Tagged Protein, CF

 9107-PL 
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Human PD-L2/B7-DC Alexa Fluor® 488-conjugated Antibody

FlowFAB1224G 
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Recombinant Cynomolgus PD-L2/B7-DC Fc Chimera Protein, CF

 9178-PL 
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Human PD-L2/B7-DC Biotinylated Antibody

WBBAF1224 
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Mouse PD-L2/B7-DC PE-conjugated Antibody

FlowFAB1022P 
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Human PD-L2/B7-DC DuoSet ELISA

ELISADY1224 
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Human PD-L2/B7-DC APC-conjugated Antibody

FlowFAB1224A 
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Mouse PD-L2/B7-DC Fluorescein-conjugated Antibody

FlowFAB1022F 
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Human PD-L2/B7-DC (NP_079515) VersaClone cDNA

RDC1133 
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Mouse PD-L2/B7-DC (NP_067371) VersaClone cDNA

RDC1183 
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Recombinant Human PD-L2/B7-DC His-tag Protein, CF

 9075-PL 
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Cynomolgus Monkey PD-L2/B7-DC (XP_005581839) VersaClone cDNA

RDC1291 
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