Filter Results

PD-L1/B7-H1: Products

PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells.

Showing 1-3 out of 3 PD-L1/B7-H1 Products

page of 1
Results Per Page
DescriptionApplicationCat#CitationsImages 

Mouse PD-L1/B7-H1 (NP_068693) VersaClone cDNA

RDC0752 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Human PD-L1/B7-H1 (NP_054862) VersaClone cDNA

RDC1087 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Cynomolgus Monkey PD-L1/B7-H1 (XP_005581836) VersaClone cDNA

RDC1288 
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
page of 1
Results Per Page