PD-L2/B7-DC: Products

PD-L2 (Programmed Death Ligand 2), also known as B7-DC and butyrophilin-like protein, is a transmembrane protein expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites, PD-L2 is upregulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand upregulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.

Showing 1-11 out of 11 PD-L2/B7-DC Products

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B/N, Flow, IHC, WBAF10222  
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Flow, IHC, WBMAB12242  
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B/N, IHC, WBAF12241  
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FlowFAB1224A 
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IHC, WBBAF1022 
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Flow, WBMAB1022 
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FlowFAB1224P 
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FlowFAB1224G 
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FlowFAB1022F 
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FlowFAB1022P 
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WBBAF1224 
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