PILR-alpha: Products

PILR-alpha (paired immunoglobulin-like type 2 receptor-alpha; also named FDF03) is one of two members of a small family of immunoregulatory Ig-superfamily receptors. It is a counterpart to PILR-beta and it likely gave rise to PILR-beta through gene duplication and rearrangement. The PILRs represent one of many pairs of Ig-like domain-containing receptors that participate in immune regulation. PILR-alpha and -beta should not be confused with the similarly named PIRs (also paired immunoglobulin-like receptors), or the functionally-related SIRP and ILT/LILR/CD85/LIR family of receptors. While PIRs, ILTs and SIRPs contain three to six Ig-like domains in their extracellular region, PILR-alpha and -beta show only one Ig-like region in their extracellular domain (ECD). Mouse PILR-alpha is a monomeric, 271 amino acid (aa) type I transmembrane (TM) protein. It contains a 167 aa ECD, a 21 aa TM segment, and a long, 83 aa cytoplasmic region. The ECD shows one V-type Ig-like domain between aa 39-157, while the cytoplasmic region contains two ITIMs (immunoreceptor Tyr-based inhibitory motifs) between aa 265-270 and 294-299. Given that ITIMs are known to interact with phosphatases such as PTPN6 and PTPN11, the presence of these motifs makes mouse PILR-alpha an inhibitory receptor. In human, activation of PILR-alpha inhibits CD32/Fc gamma RII-induced calcium mobilization. Although CD99 is a known ligand for both PILR-alpha and -beta, highest affinity binding seems to occur between CD99 and PILR-alpha. Mouse PILR-alpha is found on neutrophils and macrophages. Mouse PILR-alpha ECD is 43% and 69% aa identical to human and rat PILR-alpha ECD, respectively; it is 75% aa identical to the ECD of mouse PILR-beta. One potential isoform of PILR-alpha has been reported. It varies only within the first 28 aa of the signal sequence.

Showing 1-11 out of 11 PILR-alpha Products

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Human PILR-alpha Antibody

WBMAB6484 
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Mouse PILR-alpha Antibody

Flow, WBAF4318 
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Human PILR-alpha Alexa Fluor® 488-conjugated Antibody

FlowFAB6484G 
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Human PILR-alpha APC-conjugated Antibody

FlowFAB6484A 
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Recombinant Human PILR-alpha Protein, CF

 6484-PR 
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Human PILR-alpha PE-conjugated Antibody

FlowFAB6484P 
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Mouse PILR-alpha PE-conjugated Antibody

FlowFAB4318P 
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Human PILR-alpha Antibody

FlowAF6484 
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Mouse PILR-alpha Alexa Fluor® 488-conjugated Antibody

FlowFAB4318G 
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Recombinant Mouse PILR-alpha Protein, CF

 4318-PR 
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Human PILR-alpha (NP_038467) VersaClone cDNA

RDC1528 
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