PSMA/FOLH1/NAALADase I: Products

Human prostate-specific membrane antigen (PSMA), a tumor marker in prostate cancer encoded by the FOLH1 gene, is a type II transmembrane zinc metallopeptidase. PSMA is most highly expressed in the nervous system, prostate, kidney, and small intestine. The enzyme is also known as glutamate carboxypeptidase II (GCPII), folate hydrolase 1, folypoly-gamma-glutamate carboxypeptidase (FGCP), and N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I).

In the brain, PSMA hydrolyzes the neurotransmitter N-acetyl-Asp-Glu to produce glutamate, another neurotransmitter. Inhibition of brain PSMA activity is considered to be a promising approach for the treatment of neurological disorders associated with glutamate excitotoxicity, such as stroke, chronic pain, and amyotrophic lateral sclerosis. Intestinal PSMA hydrolyzes folylpoly-gamma-glutamates, facilitating the uptake of folate.

Showing 1-15 out of 15 PSMA/FOLH1/NAALADase I Products

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Recombinant Human PSMA/FOLH1 Protein, CF

 4234-ZN 
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Human PSMA/FOLH1/NAALADase I Antibody

Flow, ICC/IF, IHC, WBMAB4234 
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Human PSMA/FOLH1/NAALADase I Antibody

Flow, IHC, WBAF4234 
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PMPA (NAALADase inhibitor)


GCP II inhibitor
1380 
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Recombinant Mouse PSMA/FOLH1 Protein, CF

 4946-ZN 
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Human PSMA/FOLH1/NAALADase I APC-conjugated Antibody

FlowFAB4234A 
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Human PSMA/FOLH1/NAALADase I PE-conjugated Antibody

FlowFAB4234P 
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Human PSMA/FOLH1/NAALADase I PerCP-conjugated Antibody

FlowFAB4234C 
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Human PSMA/FOLH1/NAALADase I Biotinylated Antibody

WBBAF4234 
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ZJ 43


Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor
2675 
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2-MPPA


Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable
5033 
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Human PSMA/FOLH1/NAALADase I PE-conjugated Antibody

FlowK0142-5 
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Human PSMA/FOLH1/NAALADase I Fluorescein-conjugated Antibody

FlowK0142-4 
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